Title : Efficacy and feasibility of a multimodal non-pharmacological intervention for mild cognitive impairment: A pilot study
Abstract:
Aim: To evaluate the implementation effects of the NEURO Plan in patients with mild cognitive impairment.
Methods: 30 patients were randomly allocated to either a control group or an intervention group. The control group received health education and the intervention group received an additional 8-weeks NEURO plan, which encompassed four components: Nutrition, Exercise, Unit-based social, and Reinforce-cognitive training. Data were collected at baseline and at 8 weeks. The primary outcome was global cognitive function. Secondary outcomes included social support, depressive symptom and quality of life.
Results: A total of 30 patients completed the entire intervention, and no adverse events were reported. In terms of cognitive function, the Mini-Mental State Examination score was 25.27±2.89 in the intervention group and 22.73±2.58 in the control group (P < 0.05). Regarding social support and depressive status, the intervention group showed a significant increase from baseline, and the post-intervention level was also significantly superior to that of the control group (P < 0.05). For quality of life, in the physical health domain, the intervention group demonstrated significant improvement both within the group and compared to the control group (P < 0.05). As for the mental health domain, both groups exhibited considerable improvement from baseline (P < 0.05), but not statistically significant difference was observed between the two groups(P > 0.05).
Conclusions: The NEURO Plan demonstrates potential efficacy in improving cognitive function and slowing disease progression in patients with mild cognitive impairment. Additionally, it shows benefits in enhancing social support, alleviating anxiety, and promoting overall psychological well-being. This study provides preliminary evidence supporting the integration of non-pharmacological intervention into clinical management strategies for mild cognitive impairment.
Keywords: Mild Cognitive Impairment, Non-Pharmacological Intervention, Nursing, Randomized Controlled Trial
